Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. Cytomegalovirus and Epstein-Barr virus infections among pediatric kidney transplant recipients at a center using universal valganciclovir prophylaxis. Consult your doctor before breast-feeding. Compare formulary status to other drugs in the same class. Minor/Significance Unknown. Valcyte is used in adults to prevent infection with cytomegalovirus (CMV) that may occur after an organ transplant (heart, kidney, or pancreas). Minor/Significance Unknown. kidney transplant patients using valganciclovir for CMV prophylaxis: Demographic and dosing data: Age, height, weight, serum creatinine (SCr), start and end dates of valganciclovir therapy, and the prescribed valganciclovir doses. Valcyte tablets are indicated for the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS). As such this unique volume will be essential to basic researchers in drug discovery and viral pathogenesis, as well as clinicians involved in antiviral chemotherapy. If it is near the time of the next dose, skip the missed dose. Comment: Coadministration of emtricitabine with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of emtricitabine. Minor/Significance Unknown. Minor/Significance Unknown. Otherwise, call a poison control center right away. Either increases levels of the other by decreasing renal clearance. What Is Valcyte? Based on the results of the IMPACT study, Valcyte prophylaxis for 200 days in kidney transplant patients resulted in a reduction in CMV disease. Minor/Significance Unknown. Minor (1)mefenamic acid will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. Minor/Significance Unknown. Avoid contact with broken/crushed tablets and the liquid form of this medication on your skin, in your mucous membranes and eyes, and avoid breathing in the dust from the tablets. The key to maintaining a successful transplant for the rest of your life is taking the immunosuppressant medications prescribed to you. Comment: Increased risk of hematologic toxicity. Use Caution/Monitor. Monitor Closely (1)valganciclovir, lamivudine. aspirin/citric acid/sodium bicarbonate will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. This drug is available at the lowest co-pay. You should not breastfeed if you take VALCYTE. Inreased risk of myelosuppression. @08��1�[�fwT~��%h��w��>��}(op�}�����C��
y�j���vZ���|at4��,��f �mM�ϼq��JZS> ,fw�3�/a����������N� If you have HIV, do not breast-feed because breast milk can transmit HIV. Caillard S, Porcher R, Provot F, et al. Minor/Significance Unknown. All material on this website is protected by copyright, Copyright © 1994-2021 by WebMD LLC. We have recently noted an increased incidence … Please confirm that you would like to log out of Medscape. o Based on the results of the IMPACT study, Valcyte prophylaxis for 200 days in kidney transplant patients resulted in a reduction in CMV disease. heart transplant recipients and kidney/pancreas recipients. Increased risk of hematologic toxicity. Controlled studies in pregnant women show no evidence of fetal risk. Valacyclovir has also been Participating patients, pharmacies, physician offices, and hospitals are responsible for reporting the receipt of all Program benefits as required by any insurer or by law. Do not double the dose to catch up. Do not change your dose or stop taking it even for a short time unless directed to do so by your doctor. ketorolac intranasal will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. Am J Transplant 2012; 12: 682. xս�7���=�")�bRd&��R�TE]�R����K������9sJ{NO}�'����f��D<2�;�w� �����W?_����7�����e����rky��ص~����x{\]��/�_mv�_�ry����_�߿_]
W������W�������P7��~�x���Á�ַ����˚w��n��&�^�.������^���| ������⿂GZ���~���ܻ�W���G/�VW��_\m����^d��X��嫬��K{�6�����mO^;�������zPE��������z�}]��vG(���=T�{�Dh۵ж��2���*tr0�yq������:��6�ޅ2vg�b����! Consult your doctor for more details.It is unknown if this medication passes into breast milk. Begin within 10 days of transplant until 200 days post-transplant, Begin within 10 days of transplant until 100 days post-transplant, CrCl 40-59 mL/min: 450 mg PO q12hr (induction), THEN 450 mg qDay, CrCl 25-39 mL/min: 450 mg PO qDay (induction), THEN 450 mg q2days, CrCl 10-24 mL/min: 450 mg PO q2days (induction), THEN 450 mg 2 times/week, <10 mL/min (on hemodialysis): Not recommended, Viracta Therapeutics, Inc; 2533 South Coast Highway, Suite 210; Carlsbad, California 92007, <4 months: Safety and efficacy not established, 4 months to 16 years: Daily dose (mg) = 7 x BSA x CrCl; not to exceed 900 mg/day, Begin within 10 days of transplant and continue until 200 days post-transplant, <1 month: Safety and efficacy not established, 1 month to 16 years: Daily dose (mg) = 7 x BSA x CrCl; not to exceed 900 mg/day, Begin within 10 days of transplant and continue until 100 days post-transplant, BSA (m²) = height (cm) X weight (kg) divided by 3600, CrCl (mL/min/1.73 m²) = K x height (cm) divided by serum Cr (mg/dL), If CrCl exceeds 150 mL/min/1.73 m², then use maximum value of 150 mL/min/1.73 m²; an upper limit of 150 mL/min/1.73 m² helps prevent the potential for over dosing, If the calculated pediatric dose exceeds 900 mg, a dose of 900 mg should be given to the child, 0.33 for infants aged <1 yr with low birth weight for gestational age, 0.45 for infants aged <1 yr with birth weight appropriate for gestational age, 0.55 for boys aged 2 to <13 yr and girls aged 2 to <16 yr, elvitegravir/cobicistat/emtricitabine/tenofovir DF, Dyspepsia, constipation, abdominal distention, mouth ulceration, Fatigue, pain, malaise, asthenia, chills, peripheral edema, Candida infections including oral candidiasis, upper respiratory tract infection, influenza, urinary tract infection, pharyngitis/nasopharyngitis, postoperative wound infection, Postoperative complications, wound secretion, Decreased appetite, hyperkalemia, hypophosphatemia, weight decreased, Back pain, myalgia, arthralgia, muscle spasms, Insomnia, neuropathy peripheral, dizziness, Renal impairment, creatinine clearance renal decreased, blood creatinine increased, hematuria, Imipenem-cilastatin: Seizures were reported in patients receiving ganciclovir and imipenem-cilastatin; concomitant use is not recommended unless the potential benefits outweigh the risks, Cyclosporine or amphotericin B: Coadministration may increase the risk of nephrotoxicity; monitor renal function, Mycophenolate mofetil (MMF): Coadministration with valganciclovir may increase the risk of hematological and renal toxicity; monitor for ganciclovir and MMF toxicity, Other drugs associated with myelosuppression or nephrotoxicity: Due to potential for increased toxicity, consider concomitant use with valganciclovir only if the potential benefits are judged to outweigh the risks, Didanosine: Ganciclovir coadministered with didanosine may increase didanosine levels; monitor for didanosine toxicity (eg, pancreatitis), Probenecid: May increase ganciclovir levels; monitor for evidence of ganciclovir toxicity, Most maternal CMV infections are asymptomatic or they may be associated with a self-limited mononucleosis-like syndrome; however, in immunocompromised patients (i.e., transplant patients or patients with AIDS), CMV infections may be symptomatic and may result in significant maternal morbidity and mortality; transmission of CMV to the fetus is a result of maternal viremia and transplacental infection; perinatal infection can also occur from exposure of the neonate to CMV shedding in the genital tract; approximately 10% of children with congenital CMV infection are symptomatic at birth; mortality in these infants is about 10% and approximately 50-90% of symptomatic surviving newborns experience significant morbidity, including mental retardation, sensorineural hearing loss, microcephaly, seizures, and other medical problems; risk of congenital CMV infection resulting from primary maternal CMV infection may be higher and of greater severity than that resulting from maternal reactivation of CMV infection, Females of reproductive potential should undergo pregnancy testing before initiation of therapy, Females: Because of mutagenic and teratogenic potential, females of reproductive potential should be advised to use effective contraception during treatment and for at least 30 days following treatment, Males: Because of its mutagenic potential, males should be advised to use condoms during and for at least 90 days following, treatment, Recommended doses may cause temporary or permanent female and male infertility, Refrigerate at 2-8°C (36-46°F) for no longer than 49 days, Write the date of expiration of the constituted oral solution on the bottle label. This book details all aspects of lung transplantation and equips the general pulmonologist/physician with the necessary tools and knowledge to assist patients with the preparation for and care post lung transplantation. Either increases toxicity of the other by pharmacodynamic synergism. acemetacin will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. The Program does not obligate the use of any specific product or provider. Your list will be saved and can be edited at any time. valganciclovir, abacavir. Use Caution/Monitor. VALCYTE does not cure CMV retinitis. STORAGE: Store the tablets at room temperature away from light and moisture. Either increases toxicity of the other by Other (see comment). Monitor Closely (1)mycophenolate will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. This medication comes in tablet and liquid forms. VALCYTE can cause seizures, dizziness, and confusion. Methods. Minor/Significance Unknown. Minor/Significance Unknown. To prevent pregnancy, men with female partners should always use effective barrier protection (such as latex or polyurethane condoms) during all sexual activity during treatment and for at least 90 days after stopping the medication. Minor/Significance Unknown. The effects and the dosages of ganciclovir and valganciclovir are not equal.Keep all medical and laboratory appointments.Tell your doctor if your condition worsens (such as worsening vision). Minor/Significance Unknown. Interestingly, valacyclovir was also associated with a decreased incidence of acute rejection in this trial. meclofenamate will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. When CMV virus infects the eyes, it is called CMV retinitis. Pediatric use information for pediatric kidney transplant patients ages 4 months to 16 years and for pediatric heart transplant patients ages 1 to less than 4 months is approved for Roche Palo Alto LLC' s VALCYTE (valganciclovir hydrochloride) tablets. commonly, these are "non-preferred" brand drugs or specialty
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